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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ACTB

Gene description

Actin, beta

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

High myoepithelial expression in all tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 3 antibodies.
HPA041264 , HPA041271 , CAB002621
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ACTB

Synonyms

Description

Actin, beta (HGNC Symbol)

Entrez gene summary

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p22.1

Chromosome location (bp)

5527151 - 5563784

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000075624 (version 83.38)

Entrez gene

60

UniProt

P60709 (UniProt - Evidence at protein level)

neXtProt

NX_P60709

Antibodypedia

ACTB antibodies

PROTEIN BROWSER

ACTB-001
ACTB-008
ACTB-009
ACTB-010
ACTB-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTB-001
ENSP00000349960
ENST00000331789
P60709 [Direct mapping]
Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed
Q1KLZ0 [Target identity:100%; Query identity:100%]
HCG15971, isoform CRA_a; PS1TP5-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001895 [retina homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006325 [chromatin organization]
GO:0006457 [protein folding]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0019894 [kinesin binding]
GO:0021762 [substantia nigra development]
GO:0030529 [ribonucleoprotein complex]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045216 [cell-cell junction organization]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050998 [nitric-oxide synthase binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0070688 [MLL5-L complex]
GO:0072562 [blood microparticle]
GO:0097433 [dense body]
Show all
375 aa
41.7 kDa
No 0
ACTB-008
ENSP00000407473
ENST00000432588
E7EVS6 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
164 aa
18 kDa
No 0
ACTB-009
ENSP00000393951
ENST00000443528
C9JZR7 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
103 aa
11.4 kDa
No 0
ACTB-010
ENSP00000401032
ENST00000414620
C9JTX5 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
80 aa
8.5 kDa
No 0
ACTB-012
ENSP00000399487
ENST00000417101
C9JUM1 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
99 aa
11 kDa
No 0

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