Expression of MOCOS in cancer - Summary

CANCER ATLAS

Gene description

Molybdenum cofactor sulfurase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039412	HPA047958

GENE INFORMATION
Gene name	MOCOS (HGNC Symbol)
Synonyms	FLJ20733, HMCS, MOS
Description	Molybdenum cofactor sulfurase (HGNC Symbol)
Entrez gene summary	MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	36187519 - 36272157
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075643 (version 83.38)
Entrez gene	55034
UniProt	Q96EN8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96EN8
Antibodypedia	MOCOS antibodies

PROTEIN BROWSER

MOCOS-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOCOS-001 ENSP00000261326 ENST00000261326	Q96EN8 [Direct mapping] Molybdenum cofactor sulfurase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0008265 [Mo-molybdopterin cofactor sulfurase activity] GO:0016740 [transferase activity] GO:0016829 [lyase activity] GO:0030151 [molybdenum ion binding] GO:0030170 [pyridoxal phosphate binding] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0043545 [molybdopterin cofactor metabolic process] GO:0044281 [small molecule metabolic process] Show all	888 aa 98.1 kDa	No	0