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MOCOS

GENERAL INFORMATION

Gene name

 MOCOS

Gene description

 Molybdenum cofactor sulfurase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (adrenal gland)
FANTOM5:Tissue enhanced (small intestine, liver)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA039412 , HPA047958
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, liver)

GENE INFORMATION

Gene name

 MOCOS (HGNC Symbol)

Synonyms

 FLJ20733, HMCS, MOS

Description

 Molybdenum cofactor sulfurase (HGNC Symbol)

Entrez gene summary

 MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]

Chromosome

 18

Cytoband

 q12.2

Chromosome location (bp)

 36187519 - 36272157

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075643 (version 83.38)

Entrez gene

 55034

UniProt

 Q96EN8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96EN8

Antibodypedia

 MOCOS antibodies

PROTEIN BROWSER
MOCOS-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOCOS-001
ENSP00000261326
ENST00000261326
Q96EN8 [Direct mapping]
Molybdenum cofactor sulfurase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0008265 [Mo-molybdopterin cofactor sulfurase activity]
GO:0016740 [transferase activity]
GO:0016829 [lyase activity]
GO:0030151 [molybdenum ion binding]
GO:0030170 [pyridoxal phosphate binding]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0043545 [molybdopterin cofactor metabolic process]
GO:0044281 [small molecule metabolic process]
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 888 aa
98.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.