Fields »
ABOUT
HELP
BLOG
RGS11

CANCER ATLAS

Gene description

 Regulator of G-protein signaling 11

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041692
HPA043039

GENE INFORMATION

Gene name

 RGS11

Synonyms

Description

 Regulator of G-protein signaling 11 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 268301 - 275980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076344 (version 83.38)

Entrez gene

 8786

UniProt

 O94810 (UniProt - Evidence at protein level)

neXtProt

 NX_O94810

Antibodypedia

 RGS11 antibodies

PROTEIN BROWSER
RGS11-001
RGS11-003
RGS11-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS11-001
ENSP00000380876
ENST00000397770
O94810 [Direct mapping]
Regulator of G-protein signaling 11
Q4TT70 [Target identity:100%; Query identity:100%]
Regulator of G-protein signaling 11; Regulator of G-protein signalling 11; Regulator of G-protein signalling 11, isoform CRA_e
Show all
Predicted intracellular proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0031681 [G-protein beta-subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0044292 [dendrite terminus]
Show all
 467 aa
52.9 kDa 		No 0
RGS11-003
ENSP00000319069
ENST00000316163
O94810 [Direct mapping]
Regulator of G-protein signaling 11
Show all
Predicted intracellular proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0031681 [G-protein beta-subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
Show all
 446 aa
50.7 kDa 		No 0
RGS11-004
ENSP00000352778
ENST00000359740
O94810 [Direct mapping]
Regulator of G-protein signaling 11
Show all
Predicted intracellular proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0031681 [G-protein beta-subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
Show all
 456 aa
51.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.