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RGS11

GENERAL INFORMATION

Gene name

 RGS11

Gene description

 Regulator of G-protein signaling 11

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA041692 , HPA043039
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 RGS11

Synonyms

Description

 Regulator of G-protein signaling 11 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 268301 - 275980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076344 (version 83.38)

Entrez gene

 8786

UniProt

 O94810 (UniProt - Evidence at protein level)

neXtProt

 NX_O94810

Antibodypedia

 RGS11 antibodies

PROTEIN BROWSER
RGS11-001
RGS11-003
RGS11-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS11-001
ENSP00000380876
ENST00000397770
O94810 [Direct mapping]
Regulator of G-protein signaling 11
Q4TT70 [Target identity:100%; Query identity:100%]
Regulator of G-protein signaling 11; Regulator of G-protein signalling 11; Regulator of G-protein signalling 11, isoform CRA_e
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Predicted intracellular proteins
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GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0031681 [G-protein beta-subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0044292 [dendrite terminus]
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 467 aa
52.9 kDa 		No 0
RGS11-003
ENSP00000319069
ENST00000316163
O94810 [Direct mapping]
Regulator of G-protein signaling 11
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Predicted intracellular proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0031681 [G-protein beta-subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
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 446 aa
50.7 kDa 		No 0
RGS11-004
ENSP00000352778
ENST00000359740
O94810 [Direct mapping]
Regulator of G-protein signaling 11
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Predicted intracellular proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0031681 [G-protein beta-subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
Show all
 456 aa
51.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.