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TYR

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GENERAL INFORMATION

Gene name

 TYR

Gene description

 Tyrosinase

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enriched (SK-MEL-30)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA043241 , HPA050889
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SK-MEL-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA043241 SK-MEL-30 Vesicles
HPA050889 SK-MEL-30 Vesicles

GENE INFORMATION

Gene name

 TYR (HGNC Symbol)

Synonyms

 OCA1, OCA1A, OCAIA

Description

 Tyrosinase (HGNC Symbol)

Entrez gene summary

 The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

Chromosome

 11

Cytoband

 q14.3

Chromosome location (bp)

 89177452 - 89295759

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077498 (version 83.38)

Entrez gene

 7299

UniProt

 P14679 (UniProt - Evidence at protein level)

neXtProt

 NX_P14679

Antibodypedia

 TYR antibodies

PROTEIN BROWSER
TYR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TYR-001
ENSP00000263321
ENST00000263321
P14679 [Direct mapping]
Tyrosinase
L8B082 [Target identity:100%; Query identity:100%]
Tyrosinase; Tyrosinase (Oculocutaneous albinism IA), isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
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GO:0004497 [monooxygenase activity]
GO:0004503 [monophenol monooxygenase activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0006583 [melanin biosynthetic process from tyrosine]
GO:0006726 [eye pigment biosynthetic process]
GO:0007601 [visual perception]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009411 [response to UV]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0033162 [melanosome membrane]
GO:0033280 [response to vitamin D]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042438 [melanin biosynthetic process]
GO:0042470 [melanosome]
GO:0042803 [protein homodimerization activity]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048538 [thymus development]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
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 529 aa
60.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.