Expression of PIAS2 in cancer - Summary

CANCER ATLAS

Gene description

Protein inhibitor of activated STAT, 2

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA068792

GENE INFORMATION
Gene name	PIAS2 (HGNC Symbol)
Synonyms	miz, PIASX-ALPHA, PIASX-BETA, ZMIZ4
Description	Protein inhibitor of activated STAT, 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	46803224 - 46920160
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078043 (version 83.38)
Entrez gene	9063
UniProt	O75928 (UniProt - Evidence at protein level)
neXtProt	NX_O75928
Antibodypedia	PIAS2 antibodies

PROTEIN BROWSER

PIAS2-002	PIAS2-005	PIAS2-006	PIAS2-008	PIAS2-009	PIAS2-012	PIAS2-014	PIAS2-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIAS2-002 ENSP00000317163 ENST00000324794	O75928 [Direct mapping] E3 SUMO-protein ligase PIAS2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0030521 [androgen receptor signaling pathway] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050681 [androgen receptor binding] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0061665 [SUMO ligase activity] Show all	572 aa 63.4 kDa	No	0
PIAS2-005 ENSP00000479025 ENST00000592212	A0A087WUY7 [Direct mapping] E3 SUMO-protein ligase PIAS2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0019789 [SUMO transferase activity] Show all	536 aa 59.6 kDa	No	1
PIAS2-006 ENSP00000443238 ENST00000545673	B4DGW0 [Direct mapping] E3 SUMO-protein ligase PIAS2; cDNA FLJ57366, highly similar to Protein inhibitor of activated STAT2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0019789 [SUMO transferase activity] Show all	282 aa 31.2 kDa	No	0
PIAS2-008 ENSP00000465676 ENST00000585916	O75928 [Direct mapping] E3 SUMO-protein ligase PIAS2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0019789 [SUMO transferase activity] GO:0030521 [androgen receptor signaling pathway] GO:0031625 [ubiquitin protein ligase binding] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045667 [regulation of osteoblast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050681 [androgen receptor binding] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0061665 [SUMO ligase activity] Show all	621 aa 68.2 kDa	No	0
PIAS2-009 ENSP00000465312 ENST00000589917	K7EJT4 [Direct mapping] E3 SUMO-protein ligase PIAS2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0019789 [SUMO transferase activity] Show all	122 aa 13.2 kDa	No	0
PIAS2-012 ENSP00000466596 ENST00000592221	K7EMP6 [Direct mapping] E3 SUMO-protein ligase PIAS2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0019789 [SUMO transferase activity] Show all	89 aa 10.1 kDa	No	1
PIAS2-014 ENSP00000468166 ENST00000586953	K7ER97 [Direct mapping] E3 SUMO-protein ligase PIAS2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0019789 [SUMO transferase activity] Show all	88 aa 9.8 kDa	No	0
PIAS2-017 ENSP00000468017 ENST00000587810	K7EQX5 [Direct mapping] E3 SUMO-protein ligase PIAS2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0019789 [SUMO transferase activity] Show all	95 aa 10.8 kDa	No	1