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PIAS2

GENERAL INFORMATION

Gene name

 PIAS2

Gene description

 Protein inhibitor of activated STAT, 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (testis, parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA068792
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PIAS2 (HGNC Symbol)

Synonyms

 miz, PIASX-ALPHA, PIASX-BETA, ZMIZ4

Description

 Protein inhibitor of activated STAT, 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 46803224 - 46920160

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078043 (version 83.38)

Entrez gene

 9063

UniProt

 O75928 (UniProt - Evidence at protein level)

neXtProt

 NX_O75928

Antibodypedia

 PIAS2 antibodies

PROTEIN BROWSER
PIAS2-002
PIAS2-005
PIAS2-006
PIAS2-008
PIAS2-009
PIAS2-012
PIAS2-014
PIAS2-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIAS2-002
ENSP00000317163
ENST00000324794
O75928 [Direct mapping]
E3 SUMO-protein ligase PIAS2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0030521 [androgen receptor signaling pathway]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0061665 [SUMO ligase activity]
Show all
 572 aa
63.4 kDa 		No 0
PIAS2-005
ENSP00000479025
ENST00000592212
A0A087WUY7 [Direct mapping]
E3 SUMO-protein ligase PIAS2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0019789 [SUMO transferase activity]
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 536 aa
59.6 kDa 		No 1
PIAS2-006
ENSP00000443238
ENST00000545673
B4DGW0 [Direct mapping]
E3 SUMO-protein ligase PIAS2; cDNA FLJ57366, highly similar to Protein inhibitor of activated STAT2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0019789 [SUMO transferase activity]
Show all
 282 aa
31.2 kDa 		No 0
PIAS2-008
ENSP00000465676
ENST00000585916
O75928 [Direct mapping]
E3 SUMO-protein ligase PIAS2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050681 [androgen receptor binding]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0061665 [SUMO ligase activity]
Show all
 621 aa
68.2 kDa 		No 0
PIAS2-009
ENSP00000465312
ENST00000589917
K7EJT4 [Direct mapping]
E3 SUMO-protein ligase PIAS2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0019789 [SUMO transferase activity]
Show all
 122 aa
13.2 kDa 		No 0
PIAS2-012
ENSP00000466596
ENST00000592221
K7EMP6 [Direct mapping]
E3 SUMO-protein ligase PIAS2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0019789 [SUMO transferase activity]
Show all
 89 aa
10.1 kDa 		No 1
PIAS2-014
ENSP00000468166
ENST00000586953
K7ER97 [Direct mapping]
E3 SUMO-protein ligase PIAS2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0019789 [SUMO transferase activity]
Show all
 88 aa
9.8 kDa 		No 0
PIAS2-017
ENSP00000468017
ENST00000587810
K7EQX5 [Direct mapping]
E3 SUMO-protein ligase PIAS2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0019789 [SUMO transferase activity]
Show all
 95 aa
10.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.