Cell atlas - SDF4 - The Human Protein Atlas

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SDF4

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	SDF4
Gene description	Stromal cell derived factor 4
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA011249 , CAB015227
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011249	A-431	Golgi apparatus
	HPA011249	U-2 OS	Golgi apparatus
	HPA011249	U-251 MG	Golgi apparatus
	CAB015227	A-431	Golgi apparatus
	CAB015227	U-2 OS	Golgi apparatus
	CAB015227	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	SDF4 (HGNC Symbol)
Synonyms	Cab45
Description	Stromal cell derived factor 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1216908 - 1232031
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078808 (version 83.38)
Entrez gene	51150
UniProt	Q9BRK5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRK5
Antibodypedia	SDF4 antibodies

PROTEIN BROWSER

SDF4-001	SDF4-006	SDF4-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDF4-001 ENSP00000353094 ENST00000360001	Q9BRK5 [Direct mapping] 45 kDa calcium-binding protein A0A024R084 [Target identity:100%; Query identity:100%] Stromal cell derived factor 4, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005770 [late endosome] GO:0005794 [Golgi apparatus] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0009650 [UV protection] GO:0016020 [membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0021549 [cerebellum development] GO:0032059 [bleb] GO:0042802 [identical protein binding] GO:0045444 [fat cell differentiation] GO:0045471 [response to ethanol] GO:0070062 [extracellular exosome] GO:0070625 [zymogen granule exocytosis] Show all	362 aa 41.8 kDa	Yes	0
SDF4-006 ENSP00000384207 ENST00000403997	H0Y3T6 [Direct mapping] 45 kDa calcium-binding protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	243 aa 28 kDa	No	0
SDF4-007 ENSP00000263741 ENST00000263741	Q9BRK5 [Direct mapping] 45 kDa calcium-binding protein A0A024R0A9 [Target identity:100%; Query identity:100%] Stromal cell derived factor 4, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005770 [late endosome] GO:0005794 [Golgi apparatus] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0009650 [UV protection] GO:0016020 [membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0021549 [cerebellum development] GO:0032059 [bleb] GO:0042802 [identical protein binding] GO:0045444 [fat cell differentiation] GO:0045471 [response to ethanol] GO:0070062 [extracellular exosome] GO:0070625 [zymogen granule exocytosis] Show all	348 aa 39.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.