Expression of OXCT1 in cancer - Summary

CANCER ATLAS

Gene description

3-oxoacid CoA transferase 1

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012047	HPA061425

GENE INFORMATION
Gene name	OXCT1 (HGNC Symbol)
Synonyms	OXCT, SCOT
Description	3-oxoacid CoA transferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p13.1
Chromosome location (bp)	41730065 - 41870519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000083720 (version 83.38)
Entrez gene	5019
UniProt	P55809 (UniProt - Evidence at protein level)
neXtProt	NX_P55809
Antibodypedia	OXCT1 antibodies

PROTEIN BROWSER

OXCT1-001	OXCT1-002	OXCT1-003	OXCT1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OXCT1-001 ENSP00000196371 ENST00000196371	P55809 [Direct mapping] Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial A0A024R040 [Target identity:100%; Query identity:100%] Succinyl-CoA:3-ketoacid-coenzyme A transferase Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0007420 [brain development] GO:0007507 [heart development] GO:0007584 [response to nutrient] GO:0008152 [metabolic process] GO:0008260 [3-oxoacid CoA-transferase activity] GO:0008410 [CoA-transferase activity] GO:0009725 [response to hormone] GO:0014823 [response to activity] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0042182 [ketone catabolic process] GO:0042493 [response to drug] GO:0042594 [response to starvation] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0046950 [cellular ketone body metabolic process] GO:0046952 [ketone body catabolic process] GO:0060612 [adipose tissue development] Show all	520 aa 56.2 kDa	Yes	0
OXCT1-002 ENSP00000425348 ENST00000509987	E9PDW2 [Direct mapping] Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008410 [CoA-transferase activity] Show all	334 aa 36.7 kDa	No	0
OXCT1-003 ENSP00000423144 ENST00000510634	P55809 [Direct mapping] Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0008260 [3-oxoacid CoA-transferase activity] GO:0008410 [CoA-transferase activity] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046950 [cellular ketone body metabolic process] GO:0046952 [ketone body catabolic process] Show all	123 aa 13.4 kDa	No	0
OXCT1-004 ENSP00000421143 ENST00000512084	P55809 [Direct mapping] Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0008260 [3-oxoacid CoA-transferase activity] GO:0008410 [CoA-transferase activity] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046950 [cellular ketone body metabolic process] GO:0046952 [ketone body catabolic process] Show all	123 aa 13.4 kDa	No	0