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OXCT1

GENERAL INFORMATION

Gene name

 OXCT1

Gene description

 3-oxoacid CoA transferase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression, most abundant in heart and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA012047 , HPA061425
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 OXCT1 (HGNC Symbol)

Synonyms

 OXCT, SCOT

Description

 3-oxoacid CoA transferase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p13.1

Chromosome location (bp)

 41730065 - 41870519

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083720 (version 83.38)

Entrez gene

 5019

UniProt

 P55809 (UniProt - Evidence at protein level)

neXtProt

 NX_P55809

Antibodypedia

 OXCT1 antibodies

PROTEIN BROWSER
OXCT1-001
OXCT1-002
OXCT1-003
OXCT1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OXCT1-001
ENSP00000196371
ENST00000196371
P55809 [Direct mapping]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
A0A024R040 [Target identity:100%; Query identity:100%]
Succinyl-CoA:3-ketoacid-coenzyme A transferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0008260 [3-oxoacid CoA-transferase activity]
GO:0008410 [CoA-transferase activity]
GO:0009725 [response to hormone]
GO:0014823 [response to activity]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0042182 [ketone catabolic process]
GO:0042493 [response to drug]
GO:0042594 [response to starvation]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046950 [cellular ketone body metabolic process]
GO:0046952 [ketone body catabolic process]
GO:0060612 [adipose tissue development]
Show all
 520 aa
56.2 kDa 		Yes 0
OXCT1-002
ENSP00000425348
ENST00000509987
E9PDW2 [Direct mapping]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0008410 [CoA-transferase activity]
Show all
 334 aa
36.7 kDa 		No 0
OXCT1-003
ENSP00000423144
ENST00000510634
P55809 [Direct mapping]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0008152 [metabolic process]
GO:0008260 [3-oxoacid CoA-transferase activity]
GO:0008410 [CoA-transferase activity]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046950 [cellular ketone body metabolic process]
GO:0046952 [ketone body catabolic process]
Show all
 123 aa
13.4 kDa 		No 0
OXCT1-004
ENSP00000421143
ENST00000512084
P55809 [Direct mapping]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0008152 [metabolic process]
GO:0008260 [3-oxoacid CoA-transferase activity]
GO:0008410 [CoA-transferase activity]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046950 [cellular ketone body metabolic process]
GO:0046952 [ketone body catabolic process]
Show all
 123 aa
13.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.