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Most malignant cells exhibited weak to moderate nuclear immunoreactivity. Cases of colorectal cancers and malignant melanomas showed strong staining. Most malignant lymphomas, lung, gastric, pancreatic and liver cancers were negative.
GENE INFORMATION
Gene name
PPIE (HGNC Symbol)
Synonyms
CyP-33, MGC111222, MGC3736
Description
Peptidylprolyl isomerase E (cyclophilin E) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]