Cell atlas - PPIE - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PPIE

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PPIE
Gene description	Peptidylprolyl isomerase E (cyclophilin E)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA019357
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019357	CACO-2	Nuclear speckles
	HPA019357	CACO-2	Cytosol	Spatial
	HPA019357	U-2 OS	Nuclear speckles
	HPA019357	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	PPIE (HGNC Symbol)
Synonyms	CyP-33, MGC111222, MGC3736
Description	Peptidylprolyl isomerase E (cyclophilin E) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	39692182 - 39763914
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000084072 (version 83.38)
Entrez gene	10450
UniProt	Q9UNP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNP9
Antibodypedia	PPIE antibodies

PROTEIN BROWSER

PPIE-001	PPIE-002	PPIE-003	PPIE-006	PPIE-007	PPIE-008	PPIE-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPIE-001 ENSP00000312769 ENST00000324379	Q9UNP9 [Direct mapping] Peptidyl-prolyl cis-trans isomerase E Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006457 [protein folding] GO:0016018 [cyclosporin A binding] GO:0044822 [poly(A) RNA binding] GO:0045070 [positive regulation of viral genome replication] GO:0071013 [catalytic step 2 spliceosome] Show all	301 aa 33.4 kDa	No	0
PPIE-002 ENSP00000348904 ENST00000356511	Q9UNP9 [Direct mapping] Peptidyl-prolyl cis-trans isomerase E Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006457 [protein folding] GO:0016018 [cyclosporin A binding] GO:0044822 [poly(A) RNA binding] GO:0045070 [positive regulation of viral genome replication] GO:0071013 [catalytic step 2 spliceosome] Show all	296 aa 33.1 kDa	No	0
PPIE-003 ENSP00000361918 ENST00000372830	Q9UNP9 [Direct mapping] Peptidyl-prolyl cis-trans isomerase E Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006457 [protein folding] GO:0016018 [cyclosporin A binding] GO:0044822 [poly(A) RNA binding] GO:0045070 [positive regulation of viral genome replication] GO:0071013 [catalytic step 2 spliceosome] Show all	314 aa 35 kDa	No	0
PPIE-006 ENSP00000433475 ENST00000497370	E9PKY5 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	213 aa 23.8 kDa	No	0
PPIE-007 ENSP00000361925 ENST00000372835	E9PEQ6 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003676 [nucleic acid binding] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	250 aa 27.7 kDa	No	0
PPIE-008 ENSP00000436689 ENST00000470018	E9PIB0 [Direct mapping] Peptidyl-prolyl cis-trans isomerase E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	72 aa 8.2 kDa	No	0
PPIE-009 ENSP00000431714 ENST00000470213	E9PK21 [Direct mapping] Peptidyl-prolyl cis-trans isomerase E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003676 [nucleic acid binding] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	208 aa 22.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.