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RNA tissue category: Tissue enhanced (adrenal gland, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATION
Gene name
ABCB1 (HGNC Symbol)
Synonyms
ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
Description
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
