Expression of TPX2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

TPX2, microtubule-associated

Protein class

Cancer-related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005487

GENE INFORMATION
Gene name	TPX2 (HGNC Symbol)
Synonyms	C20orf1, C20orf2, DIL-2, p100
Description	TPX2, microtubule-associated (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q11.21
Chromosome location (bp)	31739271 - 31801805
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088325 (version 83.38)
Entrez gene	22974
UniProt	Q9ULW0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULW0
Antibodypedia	TPX2 antibodies

PROTEIN BROWSER

TPX2-001	TPX2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPX2-001 ENSP00000300403 ENST00000300403	Q9ULW0 [Direct mapping] Targeting protein for Xklp2 Q643R0 [Target identity:100%; Query identity:100%] HCTP4; TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_b; cDNA, FLJ92922 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0006915 [apoptotic process] GO:0007067 [mitotic nuclear division] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0019901 [protein kinase binding] GO:0032147 [activation of protein kinase activity] GO:0043203 [axon hillock] GO:0051301 [cell division] GO:0060236 [regulation of mitotic spindle organization] GO:0061676 [importin-alpha family protein binding] GO:0090307 [mitotic spindle assembly] Show all	747 aa 85.7 kDa	No	0
TPX2-002 ENSP00000341145 ENST00000340513	Q9ULW0 [Direct mapping] Targeting protein for Xklp2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0006915 [apoptotic process] GO:0007067 [mitotic nuclear division] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0019901 [protein kinase binding] GO:0032147 [activation of protein kinase activity] GO:0051301 [cell division] GO:0060236 [regulation of mitotic spindle organization] GO:0061676 [importin-alpha family protein binding] GO:0090307 [mitotic spindle assembly] Show all	783 aa 89.4 kDa	No	0