Fields »
ABOUT
HELP
BLOG
TPX2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 TPX2

Gene description

 TPX2, microtubule-associated

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the mitotic spindle.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Mitotic spindle (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition and custom assay

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA005487
SHOW MORE

ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the mitotic spindle.

Main location

 Nucleoplasm (supported)

Additional location

 Mitotic spindle (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA005487 A-431 Nucleoplasm Intensity
Mitotic spindle
HPA005487 U-2 OS Nucleoplasm Intensity Intensity
Mitotic spindle
HPA005487 U-251 MG Nucleoplasm Intensity
Mitotic spindle

CUSTOM DATA

 

 

 
Toggle channels

Thumbnail

Antibody

Cell line

Assay

Description
HPA005487 BJ Image Immunostaining of TPX2 in BJ primary cells displaying a strong staining in the mitotic spindle as well as a weaker nuclear staining in a subset of the cells.
 

 

 

 
Toggle channels

Thumbnail

Antibody

Cell line

Assay

Description
HPA005487 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. TPX2 is mostly expressed during S and/or G2.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition and custom assay

Intensity variation

 Nucleoplasm

GENE INFORMATION

Gene name

 TPX2 (HGNC Symbol)

Synonyms

 C20orf1, C20orf2, DIL-2, p100

Description

 TPX2, microtubule-associated (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31739271 - 31801805

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088325 (version 83.38)

Entrez gene

 22974

UniProt

 Q9ULW0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULW0

Antibodypedia

 TPX2 antibodies

PROTEIN BROWSER
TPX2-001
TPX2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPX2-001
ENSP00000300403
ENST00000300403
Q9ULW0 [Direct mapping]
Targeting protein for Xklp2
Q643R0 [Target identity:100%; Query identity:100%]
HCTP4; TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_b; cDNA, FLJ92922
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0043203 [axon hillock]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061676 [importin-alpha family protein binding]
GO:0090307 [mitotic spindle assembly]
Show all
 747 aa
85.7 kDa 		No 0
TPX2-002
ENSP00000341145
ENST00000340513
Q9ULW0 [Direct mapping]
Targeting protein for Xklp2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061676 [importin-alpha family protein binding]
GO:0090307 [mitotic spindle assembly]
Show all
 783 aa
89.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.