Fields »
ABOUT
HELP
BLOG
TPX2

GENERAL INFORMATION

Gene name

 TPX2

Gene description

 TPX2, microtubule-associated

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (testis, tonsil, appendix)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear or cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA005487
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Tonsil
N/A
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, tonsil, appendix)

GENE INFORMATION

Gene name

 TPX2 (HGNC Symbol)

Synonyms

 C20orf1, C20orf2, DIL-2, p100

Description

 TPX2, microtubule-associated (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31739271 - 31801805

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088325 (version 83.38)

Entrez gene

 22974

UniProt

 Q9ULW0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULW0

Antibodypedia

 TPX2 antibodies

PROTEIN BROWSER
TPX2-001
TPX2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPX2-001
ENSP00000300403
ENST00000300403
Q9ULW0 [Direct mapping]
Targeting protein for Xklp2
Q643R0 [Target identity:100%; Query identity:100%]
HCTP4; TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_b; cDNA, FLJ92922
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0043203 [axon hillock]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061676 [importin-alpha family protein binding]
GO:0090307 [mitotic spindle assembly]
Show all
 747 aa
85.7 kDa 		No 0
TPX2-002
ENSP00000341145
ENST00000340513
Q9ULW0 [Direct mapping]
Targeting protein for Xklp2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061676 [importin-alpha family protein binding]
GO:0090307 [mitotic spindle assembly]
Show all
 783 aa
89.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.