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NOS1

CANCER ATLAS

Gene description

 Nitric oxide synthase 1 (neuronal)

Protein class

 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB002167

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Cancer cells were negative.

GENE INFORMATION

Gene name

 NOS1 (HGNC Symbol)

Synonyms

 nNOS, NOS

Description

 Nitric oxide synthase 1 (neuronal) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]

Chromosome

 12

Cytoband

 q24.22

Chromosome location (bp)

 117208142 - 117452170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089250 (version 83.38)

Entrez gene

 4842

UniProt

 P29475 (UniProt - Evidence at protein level)

neXtProt

 NX_P29475

Antibodypedia

 NOS1 antibodies

PROTEIN BROWSER
NOS1-001
NOS1-002
NOS1-201
NOS1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOS1-001
ENSP00000320758
ENST00000317775
P29475 [Direct mapping]
Nitric oxide synthase, brain
B3VK56 [Target identity:100%; Query identity:100%]
Nitric oxide synthase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0007596 [blood coagulation]
GO:0009408 [response to heat]
GO:0010181 [FMN binding]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042383 [sarcolemma]
GO:0042738 [exogenous drug catabolic process]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043267 [negative regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045776 [negative regulation of blood pressure]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046870 [cadmium ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0055114 [oxidation-reduction process]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0090382 [phagosome maturation]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1990425 [ryanodine receptor complex]
Show all
 1434 aa
161 kDa 		No 0
NOS1-002
ENSP00000337459
ENST00000338101
P29475 [Direct mapping]
Nitric oxide synthase, brain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0007596 [blood coagulation]
GO:0009408 [response to heat]
GO:0010181 [FMN binding]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042383 [sarcolemma]
GO:0042738 [exogenous drug catabolic process]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043267 [negative regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045776 [negative regulation of blood pressure]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046870 [cadmium ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0055114 [oxidation-reduction process]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0090382 [phagosome maturation]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1990425 [ryanodine receptor complex]
Show all
 1468 aa
164.8 kDa 		No 0
NOS1-201
ENSP00000339862
ENST00000344089
C9J5P6 [Direct mapping]
Nitric oxide synthase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0010181 [FMN binding]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0045776 [negative regulation of blood pressure]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 1433 aa
161 kDa 		No 0
NOS1-202
ENSP00000477999
ENST00000618760
P29475 [Direct mapping]
Nitric oxide synthase, brain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0008016 [regulation of heart contraction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0010181 [FMN binding]
GO:0010243 [response to organonitrogen compound]
GO:0010288 [response to lead ion]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0012506 [vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030425 [dendrite]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0031667 [response to nutrient levels]
GO:0031965 [nuclear membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033197 [response to vitamin E]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0035094 [response to nicotine]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042383 [sarcolemma]
GO:0042582 [azurophil granule]
GO:0042738 [exogenous drug catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043434 [response to peptide hormone]
GO:0043627 [response to estrogen]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045471 [response to ethanol]
GO:0045776 [negative regulation of blood pressure]
GO:0045822 [negative regulation of heart contraction]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046676 [negative regulation of insulin secretion]
GO:0046870 [cadmium ion binding]
GO:0048148 [behavioral response to cocaine]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0050767 [regulation of neurogenesis]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0051930 [regulation of sensory perception of pain]
GO:0055114 [oxidation-reduction process]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071731 [response to nitric oxide]
GO:0090382 [phagosome maturation]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1901206 [positive regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1901216 [positive regulation of neuron death]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1990425 [ryanodine receptor complex]
Show all
 1468 aa
164.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.