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NOS1
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NOS1

Gene description

Nitric oxide synthase 1 (neuronal)

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (skeletal muscle)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Tissue enhanced (caudate)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
CAB002167
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin02468101214TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02468101214Tags Per Million

GENE INFORMATION

Gene name

NOS1 (HGNC Symbol)

Synonyms

nNOS, NOS

Description

Nitric oxide synthase 1 (neuronal) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]

Chromosome

12

Cytoband

q24.22

Chromosome location (bp)

117208142 - 117452170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000089250 (version 83.38)

Entrez gene

4842

UniProt

P29475 (UniProt - Evidence at protein level)

neXtProt

NX_P29475

Antibodypedia

NOS1 antibodies

PROTEIN BROWSER

NOS1-001
NOS1-002
NOS1-201
NOS1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOS1-001
ENSP00000320758
ENST00000317775
P29475 [Direct mapping]
Nitric oxide synthase, brain
B3VK56 [Target identity:100%; Query identity:100%]
Nitric oxide synthase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0007596 [blood coagulation]
GO:0009408 [response to heat]
GO:0010181 [FMN binding]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042383 [sarcolemma]
GO:0042738 [exogenous drug catabolic process]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043267 [negative regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045776 [negative regulation of blood pressure]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046870 [cadmium ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0055114 [oxidation-reduction process]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0090382 [phagosome maturation]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1990425 [ryanodine receptor complex]
Show all
1434 aa
161 kDa
No 0
NOS1-002
ENSP00000337459
ENST00000338101
P29475 [Direct mapping]
Nitric oxide synthase, brain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0007596 [blood coagulation]
GO:0009408 [response to heat]
GO:0010181 [FMN binding]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042383 [sarcolemma]
GO:0042738 [exogenous drug catabolic process]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043267 [negative regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045776 [negative regulation of blood pressure]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046870 [cadmium ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0055114 [oxidation-reduction process]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0090382 [phagosome maturation]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1990425 [ryanodine receptor complex]
Show all
1468 aa
164.8 kDa
No 0
NOS1-201
ENSP00000339862
ENST00000344089
C9J5P6 [Direct mapping]
Nitric oxide synthase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0010181 [FMN binding]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0045776 [negative regulation of blood pressure]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
1433 aa
161 kDa
No 0
NOS1-202
ENSP00000477999
ENST00000618760
P29475 [Direct mapping]
Nitric oxide synthase, brain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004517 [nitric-oxide synthase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0008016 [regulation of heart contraction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0010181 [FMN binding]
GO:0010243 [response to organonitrogen compound]
GO:0010288 [response to lead ion]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0012506 [vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030425 [dendrite]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0031667 [response to nutrient levels]
GO:0031965 [nuclear membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033197 [response to vitamin E]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0035094 [response to nicotine]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042383 [sarcolemma]
GO:0042582 [azurophil granule]
GO:0042738 [exogenous drug catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043434 [response to peptide hormone]
GO:0043627 [response to estrogen]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045471 [response to ethanol]
GO:0045776 [negative regulation of blood pressure]
GO:0045822 [negative regulation of heart contraction]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046676 [negative regulation of insulin secretion]
GO:0046870 [cadmium ion binding]
GO:0048148 [behavioral response to cocaine]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0050767 [regulation of neurogenesis]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0051930 [regulation of sensory perception of pain]
GO:0055114 [oxidation-reduction process]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071731 [response to nitric oxide]
GO:0090382 [phagosome maturation]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1901206 [positive regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1901216 [positive regulation of neuron death]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1990425 [ryanodine receptor complex]
Show all
1468 aa
164.8 kDa
No 0

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