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PTGS1

GENERAL INFORMATION

Gene name

 PTGS1

Gene description

 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Tissue enhanced (urinary bladder)
FANTOM5:Group enriched (smooth muscle, urinary bladder, prostate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in several tissues, high expression in squamous epithelia, megakaryocytes, fallopian tube, brain and subsets of cells in tissue stroma.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity support the protein profile.

Reliability score

 Supported based on 2 antibodies.
HPA002834 , CAB020315
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin020406080100120140RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (smooth muscle, urinary bladder, prostate)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina05001,0001,5002,000Tags Per Million

GENE INFORMATION

Gene name

 PTGS1 (HGNC Symbol)

Synonyms

 COX1, PGHS-1, PTGHS

Description

 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (HGNC Symbol)

Entrez gene summary

 This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 9

Cytoband

 q33.2

Chromosome location (bp)

 122370530 - 122395703

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095303 (version 83.38)

Entrez gene

 5742

UniProt

 P23219 (UniProt - Evidence at protein level)

neXtProt

 NX_P23219

Antibodypedia

 PTGS1 antibodies

PROTEIN BROWSER
PTGS1-001
PTGS1-002
PTGS1-003
PTGS1-201
PTGS1-202
PTGS1-203
PTGS1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGS1-001
ENSP00000354612
ENST00000362012
P23219 [Direct mapping]
Prostaglandin G/H synthase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0001750 [photoreceptor outer segment]
GO:0004601 [peroxidase activity]
GO:0004666 [prostaglandin-endoperoxide synthase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006693 [prostaglandin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0007568 [aging]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008217 [regulation of blood pressure]
GO:0008289 [lipid binding]
GO:0010243 [response to organonitrogen compound]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0019233 [sensory perception of pain]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0020037 [heme binding]
GO:0032811 [negative regulation of epinephrine secretion]
GO:0035633 [maintenance of blood-brain barrier]
GO:0042127 [regulation of cell proliferation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0051412 [response to corticosterone]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070542 [response to fatty acid]
Show all
 599 aa
68.7 kDa 		Yes 0
PTGS1-002
ENSP00000223423
ENST00000223423
P23219 [Direct mapping]
Prostaglandin G/H synthase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0004601 [peroxidase activity]
GO:0004666 [prostaglandin-endoperoxide synthase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0008217 [regulation of blood pressure]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0020037 [heme binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 562 aa
64.5 kDa 		Yes 0
PTGS1-003
ENSP00000411606
ENST00000426608
X6RJD6 [Direct mapping]
Prostaglandin G/H synthase 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0004666 [prostaglandin-endoperoxide synthase activity]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0008217 [regulation of blood pressure]
GO:0019371 [cyclooxygenase pathway]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 156 aa
18 kDa 		Yes 0
PTGS1-201
ENSP00000362802
ENST00000373698
P23219 [Direct mapping]
Prostaglandin G/H synthase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0004601 [peroxidase activity]
GO:0004666 [prostaglandin-endoperoxide synthase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0008217 [regulation of blood pressure]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0020037 [heme binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 490 aa
56.1 kDa 		No 0
PTGS1-202
ENSP00000437709
ENST00000540753
P23219 [Direct mapping]
Prostaglandin G/H synthase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0004601 [peroxidase activity]
GO:0004666 [prostaglandin-endoperoxide synthase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0008217 [regulation of blood pressure]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0020037 [heme binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 537 aa
61.9 kDa 		No 0
PTGS1-203
ENSP00000484800
ENST00000614910
A0A087X296 [Direct mapping]
Prostaglandin G/H synthase 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0004666 [prostaglandin-endoperoxide synthase activity]
GO:0005515 [protein binding]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0008217 [regulation of blood pressure]
GO:0019371 [cyclooxygenase pathway]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 551 aa
63.3 kDa 		Yes 0
PTGS1-204
ENSP00000483540
ENST00000619306
P23219 [Direct mapping]
Prostaglandin G/H synthase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0004601 [peroxidase activity]
GO:0004666 [prostaglandin-endoperoxide synthase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0008217 [regulation of blood pressure]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0020037 [heme binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 630 aa
72 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.