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IFT74

GENERAL INFORMATION

Gene name

 IFT74

Gene description

 Intraflagellar transport 74

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membrane expression in ciliated cells in fallopian tube and respiratory epithelia. Cytoplasmic expression in several other tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA020247 , HPA026684
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IFT74 (HGNC Symbol)

Synonyms

 CCDC2, CMG-1, CMG1, FLJ22621

Description

 Intraflagellar transport 74 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 p21.2

Chromosome location (bp)

 26947039 - 27062930

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096872 (version 83.38)

Entrez gene

 80173

UniProt

 Q96LB3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96LB3

Antibodypedia

 IFT74 antibodies

PROTEIN BROWSER
IFT74-001
IFT74-004
IFT74-005
IFT74-006
IFT74-007
IFT74-008
IFT74-201
IFT74-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFT74-001
ENSP00000369402
ENST00000380062
Q96LB3 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030992 [intraciliary transport particle B]
GO:0031514 [motile cilium]
GO:0035735 [intraciliary transport involved in cilium morphogenesis]
GO:0042384 [cilium assembly]
GO:0048487 [beta-tubulin binding]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 600 aa
69.2 kDa 		No 0
IFT74-004
ENSP00000393907
ENST00000429045
Q96LB3 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030992 [intraciliary transport particle B]
GO:0031514 [motile cilium]
GO:0035735 [intraciliary transport involved in cilium morphogenesis]
GO:0042384 [cilium assembly]
GO:0048487 [beta-tubulin binding]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 372 aa
42.3 kDa 		No 0
IFT74-005
ENSP00000430742
ENST00000517866
E5RIF0 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0030992 [intraciliary transport particle B]
GO:0042073 [intraciliary transport]
GO:0042384 [cilium assembly]
GO:0048487 [beta-tubulin binding]
Show all
 147 aa
16.4 kDa 		No 0
IFT74-006
ENSP00000430526
ENST00000518614
E5RJK3 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0030992 [intraciliary transport particle B]
GO:0042073 [intraciliary transport]
GO:0042384 [cilium assembly]
GO:0048487 [beta-tubulin binding]
Show all
 146 aa
15.3 kDa 		No 0
IFT74-007
ENSP00000430004
ENST00000519968
E5RH29 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0030992 [intraciliary transport particle B]
GO:0042073 [intraciliary transport]
GO:0042384 [cilium assembly]
GO:0048487 [beta-tubulin binding]
Show all
 175 aa
19 kDa 		No 0
IFT74-008
ENSP00000430096
ENST00000517444
E5RGX6 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0030992 [intraciliary transport particle B]
GO:0042073 [intraciliary transport]
GO:0042384 [cilium assembly]
GO:0048487 [beta-tubulin binding]
Show all
 127 aa
13.4 kDa 		No 0
IFT74-201
ENSP00000389224
ENST00000433700
Q96LB3 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030992 [intraciliary transport particle B]
GO:0031514 [motile cilium]
GO:0035735 [intraciliary transport involved in cilium morphogenesis]
GO:0042384 [cilium assembly]
GO:0048487 [beta-tubulin binding]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 600 aa
69.2 kDa 		No 0
IFT74-202
ENSP00000404122
ENST00000443698
Q96LB3 [Direct mapping]
Intraflagellar transport protein 74 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003334 [keratinocyte development]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0007219 [Notch signaling pathway]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0008544 [epidermis development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030992 [intraciliary transport particle B]
GO:0031514 [motile cilium]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035735 [intraciliary transport involved in cilium morphogenesis]
GO:0042384 [cilium assembly]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048487 [beta-tubulin binding]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0060271 [cilium morphogenesis]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 600 aa
69.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.