Cell atlas - TRIOBP - The Human Protein Atlas

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TRIOBP

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	TRIOBP
Gene description	TRIO and F-actin binding protein
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA019769
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019769	A-431	Cytosol
	HPA019769	U-2 OS	Cytosol
	HPA019769	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TRIOBP (HGNC Symbol)
Synonyms	DFNB28, HRIHFB2122, KIAA1662, TAP68, Tara
Description	TRIO and F-actin binding protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37697004 - 37776556
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100106 (version 83.38)
Entrez gene	11078
UniProt	Q9H2D6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2D6
Antibodypedia	TRIOBP antibodies

PROTEIN BROWSER

TRIOBP-001	TRIOBP-005	TRIOBP-006	TRIOBP-008	TRIOBP-010	TRIOBP-011	TRIOBP-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIOBP-001 ENSP00000384312 ENST00000406386	Q9H2D6 [Direct mapping] TRIO and F-actin-binding protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005925 [focal adhesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0017049 [GTP-Rho binding] GO:0030047 [actin modification] GO:0030496 [midbody] GO:0031625 [ubiquitin protein ligase binding] GO:0045159 [myosin II binding] GO:0051015 [actin filament binding] GO:0051016 [barbed-end actin filament capping] GO:0051301 [cell division] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] Show all	2365 aa 261.4 kDa	No	0
TRIOBP-005 ENSP00000383913 ENST00000407319	Q9H2D6 [Direct mapping] TRIO and F-actin-binding protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005925 [focal adhesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0017049 [GTP-Rho binding] GO:0030047 [actin modification] GO:0030496 [midbody] GO:0031625 [ubiquitin protein ligase binding] GO:0045159 [myosin II binding] GO:0051015 [actin filament binding] GO:0051016 [barbed-end actin filament capping] GO:0051301 [cell division] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] Show all	431 aa 47.6 kDa	No	0
TRIOBP-006 ENSP00000386026 ENST00000403663	Q9H2D6 [Direct mapping] TRIO and F-actin-binding protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005925 [focal adhesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0017049 [GTP-Rho binding] GO:0030047 [actin modification] GO:0030496 [midbody] GO:0031625 [ubiquitin protein ligase binding] GO:0045159 [myosin II binding] GO:0051015 [actin filament binding] GO:0051016 [barbed-end actin filament capping] GO:0051301 [cell division] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] Show all	652 aa 74 kDa	No	0
TRIOBP-008 ENSP00000396946 ENST00000418339	F6TR96 [Direct mapping] TRIO and F-actin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0032956 [regulation of actin cytoskeleton organization] GO:0051015 [actin filament binding] Show all	265 aa 29.6 kDa	No	0
TRIOBP-010 ENSP00000387881 ENST00000417857	F6WYE2 [Direct mapping] TRIO and F-actin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0032956 [regulation of actin cytoskeleton organization] GO:0051015 [actin filament binding] Show all	256 aa 29 kDa	No	0
TRIOBP-011 ENSP00000407542 ENST00000452519	F6WMF4 [Direct mapping] TRIO and F-actin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0032956 [regulation of actin cytoskeleton organization] GO:0051015 [actin filament binding] Show all	83 aa 9.5 kDa	No	0
TRIOBP-012 ENSP00000399006 ENST00000428075	H0Y5J9 [Direct mapping] TRIO and F-actin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0032956 [regulation of actin cytoskeleton organization] GO:0051015 [actin filament binding] Show all	311 aa 34.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.