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TRIOBP

GENERAL INFORMATION

Gene name

 TRIOBP

Gene description

 TRIO and F-actin binding protein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003747 , HPA019769
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIOBP (HGNC Symbol)

Synonyms

 DFNB28, HRIHFB2122, KIAA1662, TAP68, Tara

Description

 TRIO and F-actin binding protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 37697004 - 37776556

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100106 (version 83.38)

Entrez gene

 11078

UniProt

 Q9H2D6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2D6

Antibodypedia

 TRIOBP antibodies

PROTEIN BROWSER
TRIOBP-001
TRIOBP-005
TRIOBP-006
TRIOBP-008
TRIOBP-010
TRIOBP-011
TRIOBP-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIOBP-001
ENSP00000384312
ENST00000406386
Q9H2D6 [Direct mapping]
TRIO and F-actin-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005925 [focal adhesion]
GO:0007067 [mitotic nuclear division]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030047 [actin modification]
GO:0030496 [midbody]
GO:0031625 [ubiquitin protein ligase binding]
GO:0045159 [myosin II binding]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051301 [cell division]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 2365 aa
261.4 kDa 		No 0
TRIOBP-005
ENSP00000383913
ENST00000407319
Q9H2D6 [Direct mapping]
TRIO and F-actin-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005925 [focal adhesion]
GO:0007067 [mitotic nuclear division]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030047 [actin modification]
GO:0030496 [midbody]
GO:0031625 [ubiquitin protein ligase binding]
GO:0045159 [myosin II binding]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051301 [cell division]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 431 aa
47.6 kDa 		No 0
TRIOBP-006
ENSP00000386026
ENST00000403663
Q9H2D6 [Direct mapping]
TRIO and F-actin-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005925 [focal adhesion]
GO:0007067 [mitotic nuclear division]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030047 [actin modification]
GO:0030496 [midbody]
GO:0031625 [ubiquitin protein ligase binding]
GO:0045159 [myosin II binding]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051301 [cell division]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 652 aa
74 kDa 		No 0
TRIOBP-008
ENSP00000396946
ENST00000418339
F6TR96 [Direct mapping]
TRIO and F-actin-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0051015 [actin filament binding]
Show all
 265 aa
29.6 kDa 		No 0
TRIOBP-010
ENSP00000387881
ENST00000417857
F6WYE2 [Direct mapping]
TRIO and F-actin-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0051015 [actin filament binding]
Show all
 256 aa
29 kDa 		No 0
TRIOBP-011
ENSP00000407542
ENST00000452519
F6WMF4 [Direct mapping]
TRIO and F-actin-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0051015 [actin filament binding]
Show all
 83 aa
9.5 kDa 		No 0
TRIOBP-012
ENSP00000399006
ENST00000428075
H0Y5J9 [Direct mapping]
TRIO and F-actin-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0051015 [actin filament binding]
Show all
 311 aa
34.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.