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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CHGA
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CHGA

Gene description

Chromogranin A

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (parathyroid gland)
GTEx:Tissue enhanced (pituitary gland, stomach)
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in neuroendocrine cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 5 antibodies.
HPA017369 , CAB000023 , CAB040544 , CAB055506 , CAB058688
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland, stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION

Gene name

CHGA

Synonyms

Description

Chromogranin A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

14

Cytoband

q32.12

Chromosome location (bp)

92923080 - 92935293

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100604 (version 83.38)

Entrez gene

1113

UniProt

P10645 (UniProt - Evidence at protein level)

neXtProt

NX_P10645

Antibodypedia

CHGA antibodies

PROTEIN BROWSER

CHGA-001
CHGA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHGA-001
ENSP00000216492
ENST00000216492
P10645 [Direct mapping]
Chromogranin-A Vasostatin-1 Vasostatin-2 EA-92 ES-43 Pancreastatin SS-18 WA-8 WE-14 LF-19 Catestatin AL-11 GV-19 GR-44 ER-37 GE-25 Serpinin-RRG Serpinin p-Glu serpinin precursor
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002551 [mast cell chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006996 [organelle organization]
GO:0008217 [regulation of blood pressure]
GO:0030141 [secretory granule]
GO:0030658 [transport vesicle membrane]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0031640 [killing of cells of other organism]
GO:0032762 [mast cell cytokine production]
GO:0033604 [negative regulation of catecholamine secretion]
GO:0042583 [chromaffin granule]
GO:0042629 [mast cell granule]
GO:0042698 [ovulation cycle]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045576 [mast cell activation]
GO:0045908 [negative regulation of vasodilation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050832 [defense response to fungus]
GO:1900738 [positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:2000707 [positive regulation of dense core granule biogenesis]
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457 aa
50.7 kDa
Yes 0
CHGA-003
ENSP00000334023
ENST00000334654
G5E968 [Direct mapping]
Chromogranin A (Parathyroid secretory protein 1), isoform CRA_b; Chromogranin-A
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030141 [secretory granule]
Show all
306 aa
34.3 kDa
Yes 0

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