Expression of EFS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Embryonal Fyn-associated substrate

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA001581

GENE INFORMATION
Gene name	EFS (HGNC Symbol)
Synonyms	CASS3, EFS1, EFS2, HEFS, SIN
Description	Embryonal Fyn-associated substrate (HGNC Symbol)
Entrez gene summary	The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23356402 - 23365752
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100842 (version 83.38)
Entrez gene	10278
UniProt	O43281 (UniProt - Evidence at protein level)
neXtProt	NX_O43281
Antibodypedia	EFS antibodies

PROTEIN BROWSER

EFS-001	EFS-003	EFS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EFS-001 ENSP00000340607 ENST00000351354	O43281 [Direct mapping] Embryonal Fyn-associated substrate Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0019904 [protein domain specific binding] GO:0035556 [intracellular signal transduction] Show all	468 aa 49 kDa	No	0
EFS-003 ENSP00000216733 ENST00000216733	O43281 [Direct mapping] Embryonal Fyn-associated substrate Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0017124 [SH3 domain binding] GO:0019904 [protein domain specific binding] GO:0035556 [intracellular signal transduction] Show all	561 aa 58.8 kDa	No	0
EFS-201 ENSP00000416684 ENST00000429593	O43281 [Direct mapping] Embryonal Fyn-associated substrate Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0019904 [protein domain specific binding] GO:0035556 [intracellular signal transduction] Show all	392 aa 41 kDa	No	0