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EFS

GENERAL INFORMATION

Gene name

 EFS

Gene description

 Embryonal Fyn-associated substrate

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and/or nuclear expression in selected tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA001581
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 EFS (HGNC Symbol)

Synonyms

 CASS3, EFS1, EFS2, HEFS, SIN

Description

 Embryonal Fyn-associated substrate (HGNC Symbol)

Entrez gene summary

 The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23356402 - 23365752

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100842 (version 83.38)

Entrez gene

 10278

UniProt

 O43281 (UniProt - Evidence at protein level)

neXtProt

 NX_O43281

Antibodypedia

 EFS antibodies

PROTEIN BROWSER
EFS-001
EFS-003
EFS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EFS-001
ENSP00000340607
ENST00000351354
O43281 [Direct mapping]
Embryonal Fyn-associated substrate
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0019904 [protein domain specific binding]
GO:0035556 [intracellular signal transduction]
Show all
 468 aa
49 kDa 		No 0
EFS-003
ENSP00000216733
ENST00000216733
O43281 [Direct mapping]
Embryonal Fyn-associated substrate
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0017124 [SH3 domain binding]
GO:0019904 [protein domain specific binding]
GO:0035556 [intracellular signal transduction]
Show all
 561 aa
58.8 kDa 		No 0
EFS-201
ENSP00000416684
ENST00000429593
O43281 [Direct mapping]
Embryonal Fyn-associated substrate
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0019904 [protein domain specific binding]
GO:0035556 [intracellular signal transduction]
Show all
 392 aa
41 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.