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SALL4

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GENERAL INFORMATION

Gene name

 SALL4

Gene description

 Spalt-like transcription factor 4

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (NTERA-2, BEWO, AF22)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA015291 , HPA015791
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2, BEWO, AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA015291 CACO-2 Nucleoplasm Intensity
HPA015291 SiHa Nucleoplasm Intensity
HPA015291 U-2 OS No staining    
HPA015791 CACO-2 Nucleoplasm Intensity
HPA015791 SiHa Nucleoplasm
Vesicles
HPA015791 U-2 OS No staining    

GENE INFORMATION

Gene name

 SALL4 (HGNC Symbol)

Synonyms

 dJ1112F19.1, ZNF797

Description

 Spalt-like transcription factor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.2

Chromosome location (bp)

 51782331 - 51802520

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101115 (version 83.38)

Entrez gene

 57167

UniProt

 Q9UJQ4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJQ4

Antibodypedia

 SALL4 antibodies

PROTEIN BROWSER
SALL4-001
SALL4-002
SALL4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SALL4-001
ENSP00000217086
ENST00000217086
Q9UJQ4 [Direct mapping]
Sal-like protein 4
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000792 [heterochromatin]
GO:0001701 [in utero embryonic development]
GO:0001833 [inner cell mass cell proliferation]
GO:0001843 [neural tube closure]
GO:0003281 [ventricular septum development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007507 [heart development]
GO:0009888 [tissue development]
GO:0019827 [stem cell population maintenance]
GO:0021915 [neural tube development]
GO:0030326 [embryonic limb morphogenesis]
GO:0035019 [somatic stem cell population maintenance]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 1053 aa
112.2 kDa 		No 0
SALL4-002
ENSP00000379319
ENST00000395997
Q9UJQ4 [Direct mapping]
Sal-like protein 4
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0035019 [somatic stem cell population maintenance]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 616 aa
65.7 kDa 		No 0
SALL4-201
ENSP00000360594
ENST00000371539
Q6Y8G5 [Direct mapping]
SALL4C; Sal-like protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0046872 [metal ion binding]
Show all
 276 aa
29.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.