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SALL4

GENERAL INFORMATION

Gene name

 SALL4

Gene description

 Spalt-like transcription factor 4

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (parathyroid gland, testis, thyroid gland, prostate)
GTEx:Tissue enhanced (thyroid gland, testis)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in subsets of cells in seminiferous ducts and in oocytes.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Correlation with internal RNA expression data in ovary cannot be evaluated due to cell type not available.

Reliability score

 Supported based on 2 antibodies.
HPA015291 , HPA015791
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (parathyroid gland, testis, thyroid gland, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 SALL4 (HGNC Symbol)

Synonyms

 dJ1112F19.1, ZNF797

Description

 Spalt-like transcription factor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.2

Chromosome location (bp)

 51782331 - 51802520

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101115 (version 83.38)

Entrez gene

 57167

UniProt

 Q9UJQ4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJQ4

Antibodypedia

 SALL4 antibodies

PROTEIN BROWSER
SALL4-001
SALL4-002
SALL4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SALL4-001
ENSP00000217086
ENST00000217086
Q9UJQ4 [Direct mapping]
Sal-like protein 4
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000792 [heterochromatin]
GO:0001701 [in utero embryonic development]
GO:0001833 [inner cell mass cell proliferation]
GO:0001843 [neural tube closure]
GO:0003281 [ventricular septum development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007507 [heart development]
GO:0009888 [tissue development]
GO:0019827 [stem cell population maintenance]
GO:0021915 [neural tube development]
GO:0030326 [embryonic limb morphogenesis]
GO:0035019 [somatic stem cell population maintenance]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 1053 aa
112.2 kDa 		No 0
SALL4-002
ENSP00000379319
ENST00000395997
Q9UJQ4 [Direct mapping]
Sal-like protein 4
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0035019 [somatic stem cell population maintenance]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
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 616 aa
65.7 kDa 		No 0
SALL4-201
ENSP00000360594
ENST00000371539
Q6Y8G5 [Direct mapping]
SALL4C; Sal-like protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0046872 [metal ion binding]
Show all
 276 aa
29.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.