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SLC32A1

GENERAL INFORMATION

Gene name

 SLC32A1

Gene description

 Solute carrier family 32 (GABA vesicular transporter), member 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (caudate, hypothalamus)
FANTOM5:Tissue enriched (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in processes in CNS.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining.

Reliability score

 Supported based on 3 antibodies.
HPA058859 , HPA059985 , CAB037156
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinRetinaNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin05101520TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hypothalamus)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (caudate)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200Tags Per Million

GENE INFORMATION

Gene name

 SLC32A1 (HGNC Symbol)

Synonyms

 bA122O1.1, VGAT, VIAAT

Description

 Solute carrier family 32 (GABA vesicular transporter), member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.23

Chromosome location (bp)

 38724462 - 38729372

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101438 (version 83.38)

Entrez gene

 140679

UniProt

 Q9H598 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9H598

Antibodypedia

 SLC32A1 antibodies

PROTEIN BROWSER
SLC32A1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC32A1-001
ENSP00000217420
ENST00000217420
Q9H598 [Direct mapping]
Vesicular inhibitory amino acid transporter
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007568 [aging]
GO:0008021 [synaptic vesicle]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015187 [glycine transmembrane transporter activity]
GO:0015495 [gamma-aminobutyric acid:proton symporter activity]
GO:0015812 [gamma-aminobutyric acid transport]
GO:0015816 [glycine transport]
GO:0016021 [integral component of membrane]
GO:0021766 [hippocampus development]
GO:0030425 [dendrite]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0043229 [intracellular organelle]
GO:0044292 [dendrite terminus]
GO:0044306 [neuron projection terminus]
GO:0044316 [cone cell pedicle]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051286 [cell tip]
GO:0055085 [transmembrane transport]
GO:0060077 [inhibitory synapse]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
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 525 aa
57.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.