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ARL2BP

GENERAL INFORMATION

Gene name

 ARL2BP

Gene description

 ADP-ribosylation factor-like 2 binding protein

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA043066 , HPA048440
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARL2BP (HGNC Symbol)

Synonyms

 BART, BART1, RP66

Description

 ADP-ribosylation factor-like 2 binding protein (HGNC Symbol)

Entrez gene summary

 ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q13

Chromosome location (bp)

 57245098 - 57253635

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102931 (version 83.38)

Entrez gene

 23568

UniProt

 Q9Y2Y0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2Y0

Antibodypedia

 ARL2BP antibodies

PROTEIN BROWSER
ARL2BP-001
ARL2BP-002
ARL2BP-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARL2BP-001
ENSP00000219204
ENST00000219204
Q9Y2Y0 [Direct mapping]
ADP-ribosylation factor-like protein 2-binding protein
A0A024R6U9 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor-like 2 binding protein, isoform CRA_a
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0030496 [midbody]
GO:0030695 [GTPase regulator activity]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0044281 [small molecule metabolic process]
GO:0050790 [regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051457 [maintenance of protein location in nucleus]
GO:1903506 [regulation of nucleic acid-templated transcription]
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 163 aa
18.8 kDa 		No 0
ARL2BP-002
ENSP00000454237
ENST00000563234
H3BM52 [Direct mapping]
ADP-ribosylation factor-like protein 2-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 171 aa
19.7 kDa 		No 0
ARL2BP-005
ENSP00000457465
ENST00000562023
H3BU49 [Direct mapping]
ADP-ribosylation factor-like protein 2-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 123 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.