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NECAB2

GENERAL INFORMATION

Gene name

 NECAB2

Gene description

 N-terminal EF-hand calcium binding protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (caudate, hypothalamus, cerebral cortex)
FANTOM5:Tissue enriched (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in CNS and islets of Langerhans.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA013998 , HPA014144 , CAB068211
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hypothalamus, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (caudate)

GENE INFORMATION

Gene name

 NECAB2 (HGNC Symbol)

Synonyms

 EFCBP2

Description

 N-terminal EF-hand calcium binding protein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 q23.3

Chromosome location (bp)

 83968632 - 84002776

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103154 (version 83.38)

Entrez gene

 54550

UniProt

 Q7Z6G3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z6G3

Antibodypedia

 NECAB2 antibodies

PROTEIN BROWSER
NECAB2-001
NECAB2-002
NECAB2-004
NECAB2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NECAB2-001
ENSP00000307449
ENST00000305202
Q7Z6G3 [Direct mapping]
N-terminal EF-hand calcium-binding protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0042984 [regulation of amyloid precursor protein biosynthetic process]
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 386 aa
43.2 kDa 		No 0
NECAB2-002
ENSP00000457354
ENST00000565691
H3BTW2 [Direct mapping]
N-terminal EF-hand calcium-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 303 aa
34.3 kDa 		No 0
NECAB2-004
ENSP00000455322
ENST00000566836
H3BPH6 [Direct mapping]
N-terminal EF-hand calcium-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 183 aa
20.4 kDa 		No 0
NECAB2-005
ENSP00000455713
ENST00000564166
H3BQC7 [Direct mapping]
N-terminal EF-hand calcium-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 62 aa
6.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.