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RAB11A

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GENERAL INFORMATION

Gene name

 RAB11A

Gene description

 RAB11A, member RAS oncogene family

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the microtubule organizing center.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubule organizing center (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Mouse

 Localized to the Microtubule organizing center in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
CAB013097 , HPA051697
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the microtubule organizing center.

Main location

 Microtubule organizing center (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB013097 A-431 Microtubule organizing center
CAB013097 U-2 OS Microtubule organizing center
Cytosol
CAB013097 U-251 MG Microtubule organizing center
Cytosol
HPA051697 A-431 Microtubule organizing center Intensity
HPA051697 U-2 OS Vesicles
Microtubule organizing center
HPA051697 U-251 MG Microtubule organizing center Intensity

MOUSE CELLS

Main location

 Microtubule organizing center

Mouse gene

 ENSMUSG00000004771 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA051697 NIH 3T3 Vesicles
Microtubule organizing center

GENE INFORMATION

Gene name

 RAB11A (HGNC Symbol)

Synonyms

 YL8

Description

 RAB11A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

 15

Cytoband

 q22.31

Chromosome location (bp)

 65726054 - 65891991

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103769 (version 83.38)

Entrez gene

 8766

UniProt

 P62491 (UniProt - Evidence at protein level)

neXtProt

 NX_P62491

Antibodypedia

 RAB11A antibodies

PROTEIN BROWSER
RAB11A-001
RAB11A-002
RAB11A-003
RAB11A-004
RAB11A-005
RAB11A-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB11A-001
ENSP00000261890
ENST00000261890
P62491 [Direct mapping]
Ras-related protein Rab-11A
A0A024R5Z8 [Target identity:100%; Query identity:100%]
RAB11A, member RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005771 [multivesicular body]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006833 [water transport]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006996 [organelle organization]
GO:0007080 [mitotic metaphase plate congression]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010796 [regulation of multivesicular body size]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0030133 [transport vesicle]
GO:0030424 [axon]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030953 [astral microtubule organization]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0036258 [multivesicular body assembly]
GO:0043234 [protein complex]
GO:0045335 [phagocytic vesicle]
GO:0045773 [positive regulation of axon extension]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048227 [plasma membrane to endosome transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051223 [regulation of protein transport]
GO:0051650 [establishment of vesicle localization]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070062 [extracellular exosome]
GO:0072594 [establishment of protein localization to organelle]
GO:0072659 [protein localization to plasma membrane]
GO:0090150 [establishment of protein localization to membrane]
GO:0090307 [mitotic spindle assembly]
GO:1990182 [exosomal secretion]
Show all
 216 aa
24.4 kDa 		No 0
RAB11A-002
ENSP00000455567
ENST00000564910
B4DQU5 [Direct mapping]
Ras-related protein Rab-11A; cDNA FLJ57160, highly similar to Ras-related protein Rab-11A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 146 aa
16.5 kDa 		No 0
RAB11A-003
ENSP00000456420
ENST00000569896
P62491 [Direct mapping]
Ras-related protein Rab-11A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005771 [multivesicular body]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006833 [water transport]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007080 [mitotic metaphase plate congression]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010796 [regulation of multivesicular body size]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030953 [astral microtubule organization]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0036258 [multivesicular body assembly]
GO:0043234 [protein complex]
GO:0045335 [phagocytic vesicle]
GO:0048227 [plasma membrane to endosome transport]
GO:0051650 [establishment of vesicle localization]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070062 [extracellular exosome]
GO:0072594 [establishment of protein localization to organelle]
GO:0072659 [protein localization to plasma membrane]
GO:0090150 [establishment of protein localization to membrane]
GO:0090307 [mitotic spindle assembly]
GO:1990182 [exosomal secretion]
Show all
 155 aa
17.7 kDa 		No 0
RAB11A-004
ENSP00000456638
ENST00000565075
H3BSC1 [Direct mapping]
Ras-related protein Rab-11A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 198 aa
22.5 kDa 		No 0
RAB11A-005
ENSP00000454673
ENST00000567671
H3BN38 [Direct mapping]
Ras-related protein Rab-11A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 82 aa
9.2 kDa 		No 0
RAB11A-009
ENSP00000454381
ENST00000566233
H3BMH2 [Direct mapping]
Ras-related protein Rab-11A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 155 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.