Cell atlas - TJP3 - The Human Protein Atlas

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TJP3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Nucleoplasm

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	TJP3
Gene description	Tight junction protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cell junctions. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (T-47d, BEWO, CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (validated)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA046863 , HPA053337
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, BEWO, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cell junctions. In addition localized to the nucleoplasm.

Main location

Cell Junctions (validated)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA046863	CACO-2	Nucleoplasm
HPA046863	CACO-2	Cell Junctions
HPA046863	MCF7	Nucleoplasm
HPA046863	MCF7	Cell Junctions
HPA046863	U-2 OS	Plasma membrane
HPA053337	CACO-2	Nucleoplasm
HPA053337	CACO-2	Cell Junctions
HPA053337	MCF7	Nucleoplasm
HPA053337	MCF7	Cell Junctions
HPA053337	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	TJP3 (HGNC Symbol)
Synonyms	ZO-3
Description	Tight junction protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	3708109 - 3750813
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105289 (version 83.38)
Entrez gene	27134
UniProt	O95049 (UniProt - Evidence at protein level)
neXtProt	NX_O95049
Antibodypedia	TJP3 antibodies

PROTEIN BROWSER

TJP3-001	TJP3-002	TJP3-003	TJP3-004	TJP3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TJP3-001 ENSP00000467864 ENST00000587686	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	938 aa 103.4 kDa	No	0
TJP3-002 ENSP00000439278 ENST00000541714	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	919 aa 101.4 kDa	No	0
TJP3-003 ENSP00000439991 ENST00000539908	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	883 aa 97.5 kDa	No	0
TJP3-004 ENSP00000465419 ENST00000589378	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0016324 [apical plasma membrane] GO:0030054 [cell junction] GO:2000045 [regulation of G1/S transition of mitotic cell cycle] Show all	928 aa 102.4 kDa	No	0
TJP3-005 ENSP00000468641 ENST00000590545	K7ESC0 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005923 [bicellular tight junction] Show all	123 aa 13.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.