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SP4

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GENERAL INFORMATION

Gene name

 SP4

Gene description

 Sp4 transcription factor

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB010246 , HPA040395
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (validated)

Additional location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB010246 A-431 Nucleoplasm
Cytosol
CAB010246 U-2 OS Nucleoplasm
Cytosol
CAB010246 U-251 MG Nucleoplasm
Cytosol
HPA040395 U-2 OS Nucleoplasm
Cytosol
HPA040395 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 SP4 (HGNC Symbol)

Synonyms

 HF1B, MGC130008, MGC130009, SPR-1

Description

 Sp4 transcription factor (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 p15.3

Chromosome location (bp)

 21428034 - 21514822

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105866 (version 83.38)

Entrez gene

 6671

UniProt

 Q02446 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02446

Antibodypedia

 SP4 antibodies

PROTEIN BROWSER
SP4-001
SP4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SP4-001
ENSP00000222584
ENST00000222584
Q02446 [Direct mapping]
Transcription factor Sp4
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008016 [regulation of heart contraction]
GO:0015630 [microtubule cytoskeleton]
GO:0045171 [intercellular bridge]
GO:0046872 [metal ion binding]
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 784 aa
82 kDa 		No 0
SP4-004
ENSP00000393623
ENST00000432066
C9JUS7 [Direct mapping]
Transcription factor Sp4
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   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 56 aa
5.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.