Expression of PTGDS in cancer - Summary

CANCER ATLAS

Gene description

Prostaglandin D2 synthase 21kDa (brain)

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004938	CAB009916

GENE INFORMATION
Gene name	PTGDS (HGNC Symbol)
Synonyms	L-PGDS, PGDS
Description	Prostaglandin D2 synthase 21kDa (brain) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136977505 - 136985435
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107317 (version 83.38)
Entrez gene	5730
UniProt	P41222 (UniProt - Evidence at protein level)
neXtProt	NX_P41222
Antibodypedia	PTGDS antibodies

PROTEIN BROWSER

PTGDS-001	PTGDS-003	PTGDS-008	PTGDS-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGDS-001 ENSP00000360687 ENST00000371625	P41222 [Direct mapping] Prostaglandin-H2 D-isomerase A0A024R8G3 [Target identity:100%; Query identity:100%] Prostaglandin D2 synthase 21kDa (Brain), isoform CRA_a Show all	Enzymes ENZYME proteins Isomerase Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001516 [prostaglandin biosynthetic process] GO:0004667 [prostaglandin-D synthase activity] GO:0005215 [transporter activity] GO:0005501 [retinoid binding] GO:0005504 [fatty acid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006810 [transport] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0045187 [regulation of circadian sleep/wake cycle, sleep] GO:0048471 [perinuclear region of cytoplasm] GO:0051384 [response to glucocorticoid] GO:0070062 [extracellular exosome] GO:2000255 [negative regulation of male germ cell proliferation] Show all	190 aa 21 kDa	Yes	0
PTGDS-003 ENSP00000392633 ENST00000457950	Q5SQ11 [Direct mapping] Prostaglandin-H2 D-isomerase Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006629 [lipid metabolic process] GO:0006810 [transport] Show all	195 aa 21.1 kDa	Yes	0
PTGDS-008 ENSP00000392692 ENST00000444903	H0Y4L4 [Direct mapping] Prostaglandin-H2 D-isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.4 kDa	No	0
PTGDS-010 ENSP00000397468 ENST00000446677	H0Y5A1 [Direct mapping] Prostaglandin-H2 D-isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0006810 [transport] GO:0036094 [small molecule binding] Show all	124 aa 13.7 kDa	No	0