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PTGDS

GENERAL INFORMATION

Gene name

 PTGDS

Gene description

 Prostaglandin D2 synthase 21kDa (brain)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous secreted and cytoplasmic expression at variable levels.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA004938 , CAB009916
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PTGDS (HGNC Symbol)

Synonyms

 L-PGDS, PGDS

Description

 Prostaglandin D2 synthase 21kDa (brain) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 136977505 - 136985435

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107317 (version 83.38)

Entrez gene

 5730

UniProt

 P41222 (UniProt - Evidence at protein level)

neXtProt

 NX_P41222

Antibodypedia

 PTGDS antibodies

PROTEIN BROWSER
PTGDS-001
PTGDS-003
PTGDS-008
PTGDS-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGDS-001
ENSP00000360687
ENST00000371625
P41222 [Direct mapping]
Prostaglandin-H2 D-isomerase
A0A024R8G3 [Target identity:100%; Query identity:100%]
Prostaglandin D2 synthase 21kDa (Brain), isoform CRA_a
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Enzymes
   ENZYME proteins
   Isomerase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0004667 [prostaglandin-D synthase activity]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005504 [fatty acid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0045187 [regulation of circadian sleep/wake cycle, sleep]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000255 [negative regulation of male germ cell proliferation]
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 190 aa
21 kDa 		Yes 0
PTGDS-003
ENSP00000392633
ENST00000457950
Q5SQ11 [Direct mapping]
Prostaglandin-H2 D-isomerase
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   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
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 195 aa
21.1 kDa 		Yes 0
PTGDS-008
ENSP00000392692
ENST00000444903
H0Y4L4 [Direct mapping]
Prostaglandin-H2 D-isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 62 aa
6.4 kDa 		No 0
PTGDS-010
ENSP00000397468
ENST00000446677
H0Y5A1 [Direct mapping]
Prostaglandin-H2 D-isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005576 [extracellular region]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0036094 [small molecule binding]
Show all
 124 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.