Expression of TRDMT1 in cancer - Summary

CANCER ATLAS

Gene description

TRNA aspartic acid methyltransferase 1

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036945	HPA036946	CAB009468

GENE INFORMATION
Gene name	TRDMT1 (HGNC Symbol)
Synonyms	DNMT2, RNMT1
Description	TRNA aspartic acid methyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]
Chromosome	10
Cytoband	p13
Chromosome location (bp)	17142254 - 17202054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107614 (version 83.38)
Entrez gene	1787
UniProt	O14717 (UniProt - Evidence at protein level)
neXtProt	NX_O14717
Antibodypedia	TRDMT1 antibodies

PROTEIN BROWSER

TRDMT1-001	TRDMT1-002	TRDMT1-003	TRDMT1-004	TRDMT1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRDMT1-001 ENSP00000367030 ENST00000377799	O14717 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Q6ICS7 [Target identity:100%; Query identity:100%] DNMT2 protein; HCG23994, isoform CRA_a; cDNA FLJ76302, highly similar to Homo sapiens DNA (cytosine-5-)-methyltransferase 2 (DNMT2), transcript variant a, mRNA; tRNA aspartic acid methyltransferase 1 variant 3; tRNA aspartic acid methyltransferase 1 variant 4 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001975 [response to amphetamine] GO:0003723 [RNA binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0008175 [tRNA methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0090116 [C-5 methylation of cytosine] Show all	391 aa 44.6 kDa	No	0
TRDMT1-002 ENSP00000431476 ENST00000525762	A0A0B4J214 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	137 aa 15.6 kDa	No	0
TRDMT1-003 ENSP00000324263 ENST00000313936	H0Y2T8 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		227 aa 25.8 kDa	No	0
TRDMT1-004 ENSP00000390611 ENST00000436968	H0Y4A2 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.5 kDa	No	0
TRDMT1-005 ENSP00000419625 ENST00000488990	B7Z8H2 [Direct mapping] cDNA FLJ52038, highly similar to DNA (cytosine-5)-methyltransferase-like protein 2; tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	254 aa 28.9 kDa	No	0