Cell atlas - TRDMT1 - The Human Protein Atlas

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TRDMT1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoli
	Nucleus

Human cell
	Centrosome
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TRDMT1
Gene description	TRNA aspartic acid methyltransferase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus & centrosome.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved), Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036946
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus & centrosome.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036946	A549	Nucleus
	HPA036946	A549	Nucleoli
	HPA036946	HEK 293	Centrosome
	HPA036946	U-2 OS	Nucleus
	HPA036946	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	TRDMT1 (HGNC Symbol)
Synonyms	DNMT2, RNMT1
Description	TRNA aspartic acid methyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]
Chromosome	10
Cytoband	p13
Chromosome location (bp)	17142254 - 17202054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107614 (version 83.38)
Entrez gene	1787
UniProt	O14717 (UniProt - Evidence at protein level)
neXtProt	NX_O14717
Antibodypedia	TRDMT1 antibodies

PROTEIN BROWSER

TRDMT1-001	TRDMT1-002	TRDMT1-003	TRDMT1-004	TRDMT1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRDMT1-001 ENSP00000367030 ENST00000377799	O14717 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Q6ICS7 [Target identity:100%; Query identity:100%] DNMT2 protein; HCG23994, isoform CRA_a; cDNA FLJ76302, highly similar to Homo sapiens DNA (cytosine-5-)-methyltransferase 2 (DNMT2), transcript variant a, mRNA; tRNA aspartic acid methyltransferase 1 variant 3; tRNA aspartic acid methyltransferase 1 variant 4 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001975 [response to amphetamine] GO:0003723 [RNA binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0008175 [tRNA methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0090116 [C-5 methylation of cytosine] Show all	391 aa 44.6 kDa	No	0
TRDMT1-002 ENSP00000431476 ENST00000525762	A0A0B4J214 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	137 aa 15.6 kDa	No	0
TRDMT1-003 ENSP00000324263 ENST00000313936	H0Y2T8 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		227 aa 25.8 kDa	No	0
TRDMT1-004 ENSP00000390611 ENST00000436968	H0Y4A2 [Direct mapping] tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.5 kDa	No	0
TRDMT1-005 ENSP00000419625 ENST00000488990	B7Z8H2 [Direct mapping] cDNA FLJ52038, highly similar to DNA (cytosine-5)-methyltransferase-like protein 2; tRNA (cytosine(38)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	254 aa 28.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.