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Plasma showed distinct positivity in several tissues. Normal tissues showed weak to moderate cytoplasmic staining. A subset of cells in renal tubules and rectum displayed strong immunoreactivity. Squamous epithelium of esophagus exhibited strong cytoplasmic and membranous positivity. Respiratory epithelia, liver, endocrine glands, trophoblastic cells, myocytes along with the CNS and lymphoid tissues were negative.