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The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001702 [gastrulation with mouth forming second] GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006011 [UDP-glucose metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006065 [UDP-glucuronate biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0009055 [electron carrier activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0052695 [cellular glucuronidation] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000271 [polysaccharide biosynthetic process] GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006011 [UDP-glucose metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006065 [UDP-glucuronate biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0009055 [electron carrier activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0052695 [cellular glucuronidation] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006011 [UDP-glucose metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006065 [UDP-glucuronate biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0009055 [electron carrier activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0052695 [cellular glucuronidation] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003979 [UDP-glucose 6-dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
