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PTGES3

GENERAL INFORMATION

Gene name

 PTGES3

Gene description

 Prostaglandin E synthase 3 (cytosolic)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA038672 , HPA038673 , CAB034319
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PTGES3 (HGNC Symbol)

Synonyms

 cPGES, p23, TEBP

Description

 Prostaglandin E synthase 3 (cytosolic) (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56663341 - 56688408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110958 (version 83.38)

Entrez gene

 10728

UniProt

 Q15185 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15185

Antibodypedia

 PTGES3 antibodies

PROTEIN BROWSER
PTGES3-001
PTGES3-002
PTGES3-003
PTGES3-004
PTGES3-006
PTGES3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGES3-001
ENSP00000262033
ENST00000262033
Q15185 [Direct mapping]
Prostaglandin E synthase 3
A0A024RB32 [Target identity:100%; Query identity:100%]
Prostaglandin E synthase 3 (Cytosolic), isoform CRA_a
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0001516 [prostaglandin biosynthetic process]
GO:0003720 [telomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006278 [RNA-dependent DNA replication]
GO:0007165 [signal transduction]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0034605 [cellular response to heat]
GO:0044281 [small molecule metabolic process]
GO:0050220 [prostaglandin-E synthase activity]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:1900034 [regulation of cellular response to heat]
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 160 aa
18.7 kDa 		No 0
PTGES3-002
ENSP00000389090
ENST00000456859
B4DDC6 [Direct mapping]
Prostaglandin E synthase 3; cDNA FLJ59832, moderately similar to Prostaglandin E synthase 3 (EC 5.3.99.3)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 124 aa
14.6 kDa 		No 0
PTGES3-003
ENSP00000405299
ENST00000414274
Q15185 [Direct mapping]
Prostaglandin E synthase 3
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0001516 [prostaglandin biosynthetic process]
GO:0003720 [telomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006278 [RNA-dependent DNA replication]
GO:0007165 [signal transduction]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0034605 [cellular response to heat]
GO:0044281 [small molecule metabolic process]
GO:0050220 [prostaglandin-E synthase activity]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:1900034 [regulation of cellular response to heat]
Show all
 130 aa
15 kDa 		No 0
PTGES3-004
ENSP00000414892
ENST00000448157
Q15185 [Direct mapping]
Prostaglandin E synthase 3
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0001516 [prostaglandin biosynthetic process]
GO:0003720 [telomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006278 [RNA-dependent DNA replication]
GO:0007165 [signal transduction]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0034605 [cellular response to heat]
GO:0044281 [small molecule metabolic process]
GO:0050220 [prostaglandin-E synthase activity]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:1900034 [regulation of cellular response to heat]
Show all
 139 aa
16.5 kDa 		No 0
PTGES3-006
ENSP00000402385
ENST00000436399
Q15185 [Direct mapping]
Prostaglandin E synthase 3
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0001516 [prostaglandin biosynthetic process]
GO:0003720 [telomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006278 [RNA-dependent DNA replication]
GO:0007165 [signal transduction]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0034605 [cellular response to heat]
GO:0044281 [small molecule metabolic process]
GO:0050220 [prostaglandin-E synthase activity]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:1900034 [regulation of cellular response to heat]
Show all
 127 aa
14.8 kDa 		No 0
PTGES3-201
ENSP00000482075
ENST00000614328
A0A087WYT3 [Direct mapping]
Prostaglandin E synthase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005978 [glycogen biosynthetic process]
GO:0008283 [cell proliferation]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043588 [skin development]
GO:0060430 [lung saccule development]
Show all
 164 aa
19.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.