Expression of SPSB2 in cancer - Summary

CANCER ATLAS

Gene description

SplA/ryanodine receptor domain and SOCS box containing 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA055225

GENE INFORMATION
Gene name	SPSB2 (HGNC Symbol)
Synonyms	GRCC9, SSB-2
Description	SplA/ryanodine receptor domain and SOCS box containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6870935 - 6889358
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111671 (version 83.38)
Entrez gene	84727
UniProt	Q99619 (UniProt - Evidence at protein level)
neXtProt	NX_Q99619
Antibodypedia	SPSB2 antibodies

PROTEIN BROWSER

SPSB2-002	SPSB2-003	SPSB2-004	SPSB2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPSB2-002 ENSP00000428458 ENST00000432205	E5RIC2 [Direct mapping] SPRY domain-containing SOCS box protein 2 Show all	Predicted intracellular proteins Show all		82 aa 8.8 kDa	No	0
SPSB2-003 ENSP00000428338 ENST00000524270	Q99619 [Direct mapping] SPRY domain-containing SOCS box protein 2 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	263 aa 28.6 kDa	No	0
SPSB2-004 ENSP00000430872 ENST00000523102	Q99619 [Direct mapping] SPRY domain-containing SOCS box protein 2 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	263 aa 28.6 kDa	No	0
SPSB2-005 ENSP00000431037 ENST00000519357	Q99619 [Direct mapping] SPRY domain-containing SOCS box protein 2 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	267 aa 28.6 kDa	No	0