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SPSB2

GENERAL INFORMATION

Gene name

 SPSB2

Gene description

 SplA/ryanodine receptor domain and SOCS box containing 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA055225
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 SPSB2 (HGNC Symbol)

Synonyms

 GRCC9, SSB-2

Description

 SplA/ryanodine receptor domain and SOCS box containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6870935 - 6889358

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111671 (version 83.38)

Entrez gene

 84727

UniProt

 Q99619 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99619

Antibodypedia

 SPSB2 antibodies

PROTEIN BROWSER
SPSB2-002
SPSB2-003
SPSB2-004
SPSB2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPSB2-002
ENSP00000428458
ENST00000432205
E5RIC2 [Direct mapping]
SPRY domain-containing SOCS box protein 2
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Predicted intracellular proteins
Show all
 82 aa
8.8 kDa 		No 0
SPSB2-003
ENSP00000428338
ENST00000524270
Q99619 [Direct mapping]
SPRY domain-containing SOCS box protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0016567 [protein ubiquitination]
GO:0035556 [intracellular signal transduction]
Show all
 263 aa
28.6 kDa 		No 0
SPSB2-004
ENSP00000430872
ENST00000523102
Q99619 [Direct mapping]
SPRY domain-containing SOCS box protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0016567 [protein ubiquitination]
GO:0035556 [intracellular signal transduction]
Show all
 263 aa
28.6 kDa 		No 0
SPSB2-005
ENSP00000431037
ENST00000519357
Q99619 [Direct mapping]
SPRY domain-containing SOCS box protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0016567 [protein ubiquitination]
GO:0035556 [intracellular signal transduction]
Show all
 267 aa
28.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.