Expression of GYS2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glycogen synthase 2 (liver)

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039482

GENE INFORMATION
Gene name	GYS2
Synonyms
Description	Glycogen synthase 2 (liver) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21536189 - 21604847
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111713 (version 83.38)
Entrez gene	2998
UniProt	P54840 (UniProt - Evidence at protein level)
neXtProt	NX_P54840
Antibodypedia	GYS2 antibodies

PROTEIN BROWSER

GYS2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GYS2-001 ENSP00000261195 ENST00000261195	P54840 [Direct mapping] Glycogen [starch] synthase, liver Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004373 [glycogen (starch) synthase activity] GO:0005536 [glucose binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005938 [cell cortex] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006091 [generation of precursor metabolites and energy] GO:0009749 [response to glucose] GO:0030864 [cortical actin cytoskeleton] GO:0042803 [protein homodimerization activity] GO:0043265 [ectoplasm] GO:0044281 [small molecule metabolic process] GO:0061547 [glycogen synthase activity, transferring glucose-1-phosphate] Show all	703 aa 81 kDa	No	0