Cell atlas - GYS2 - The Human Protein Atlas

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GYS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	GYS2
Gene description	Glycogen synthase 2 (liver)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (CACO-2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GYS2
Synonyms
Description	Glycogen synthase 2 (liver) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21536189 - 21604847
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111713 (version 83.38)
Entrez gene	2998
UniProt	P54840 (UniProt - Evidence at protein level)
neXtProt	NX_P54840
Antibodypedia	GYS2 antibodies

PROTEIN BROWSER

GYS2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GYS2-001 ENSP00000261195 ENST00000261195	P54840 [Direct mapping] Glycogen [starch] synthase, liver Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004373 [glycogen (starch) synthase activity] GO:0005536 [glucose binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005938 [cell cortex] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006091 [generation of precursor metabolites and energy] GO:0009749 [response to glucose] GO:0030864 [cortical actin cytoskeleton] GO:0042803 [protein homodimerization activity] GO:0043265 [ectoplasm] GO:0044281 [small molecule metabolic process] GO:0061547 [glycogen synthase activity, transferring glucose-1-phosphate] Show all	703 aa 81 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.