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GYS2

GENERAL INFORMATION

Gene name

 GYS2

Gene description

 Glycogen synthase 2 (liver)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in hepatocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA039482
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 GYS2

Synonyms

Description

 Glycogen synthase 2 (liver) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]

Chromosome

 12

Cytoband

 p12.1

Chromosome location (bp)

 21536189 - 21604847

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111713 (version 83.38)

Entrez gene

 2998

UniProt

 P54840 (UniProt - Evidence at protein level)

neXtProt

 NX_P54840

Antibodypedia

 GYS2 antibodies

PROTEIN BROWSER
GYS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GYS2-001
ENSP00000261195
ENST00000261195
P54840 [Direct mapping]
Glycogen [starch] synthase, liver
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004373 [glycogen (starch) synthase activity]
GO:0005536 [glucose binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005938 [cell cortex]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0009749 [response to glucose]
GO:0030864 [cortical actin cytoskeleton]
GO:0042803 [protein homodimerization activity]
GO:0043265 [ectoplasm]
GO:0044281 [small molecule metabolic process]
GO:0061547 [glycogen synthase activity, transferring glucose-1-phosphate]
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 703 aa
81 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.