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DBN1

CANCER ATLAS

Gene description

 Drebrin 1

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA051452
HPA056940

GENE INFORMATION

Gene name

 DBN1 (HGNC Symbol)

Synonyms

 D0S117E

Description

 Drebrin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 177456608 - 177474401

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113758 (version 83.38)

Entrez gene

 1627

UniProt

 Q16643 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16643

Antibodypedia

 DBN1 antibodies

PROTEIN BROWSER
DBN1-001
DBN1-002
DBN1-004
DBN1-006
DBN1-008
DBN1-009
DBN1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DBN1-001
ENSP00000308532
ENST00000309007
Q16643 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0042641 [actomyosin]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0050773 [regulation of dendrite development]
Show all
 649 aa
71.4 kDa 		No 0
DBN1-002
ENSP00000292385
ENST00000292385
Q16643 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005921 [gap junction]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0010643 [cell communication by chemical coupling]
GO:0010644 [cell communication by electrical coupling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0032507 [maintenance of protein location in cell]
GO:0042641 [actomyosin]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048699 [generation of neurons]
GO:0050773 [regulation of dendrite development]
GO:0061351 [neural precursor cell proliferation]
Show all
 651 aa
71.6 kDa 		No 0
DBN1-004
ENSP00000377195
ENST00000393565
Q16643 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0042641 [actomyosin]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0050773 [regulation of dendrite development]
Show all
 695 aa
76.3 kDa 		No 0
DBN1-006
ENSP00000423208
ENST00000512501
D6R9Q9 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005886 [plasma membrane]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
Show all
 391 aa
41.4 kDa 		No 0
DBN1-008
ENSP00000421465
ENST00000514833
D6RFI1 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0007015 [actin filament organization]
Show all
 124 aa
13.4 kDa 		No 0
DBN1-009
ENSP00000422854
ENST00000477391
D6R9W4 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0007015 [actin filament organization]
Show all
 317 aa
36.5 kDa 		No 0
DBN1-011
ENSP00000425546
ENST00000506117
D6RCR4 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0007015 [actin filament organization]
Show all
 93 aa
10.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.