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DBN1

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GENERAL INFORMATION

Gene name

 DBN1

Gene description

 Drebrin 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & actin filaments.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Actin filaments (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA051452
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & actin filaments.

Main location

 Plasma membrane (approved), Actin filaments (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051452 HeLa Plasma membrane
HPA051452 PC-3 Plasma membrane
HPA051452 U-2 OS Plasma membrane
Actin filaments

GENE INFORMATION

Gene name

 DBN1 (HGNC Symbol)

Synonyms

 D0S117E

Description

 Drebrin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 177456608 - 177474401

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113758 (version 83.38)

Entrez gene

 1627

UniProt

 Q16643 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16643

Antibodypedia

 DBN1 antibodies

PROTEIN BROWSER
DBN1-001
DBN1-002
DBN1-004
DBN1-006
DBN1-008
DBN1-009
DBN1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DBN1-001
ENSP00000308532
ENST00000309007
Q16643 [Direct mapping]
Drebrin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0042641 [actomyosin]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0050773 [regulation of dendrite development]
Show all
 649 aa
71.4 kDa 		No 0
DBN1-002
ENSP00000292385
ENST00000292385
Q16643 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005921 [gap junction]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0010643 [cell communication by chemical coupling]
GO:0010644 [cell communication by electrical coupling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0032507 [maintenance of protein location in cell]
GO:0042641 [actomyosin]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048699 [generation of neurons]
GO:0050773 [regulation of dendrite development]
GO:0061351 [neural precursor cell proliferation]
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 651 aa
71.6 kDa 		No 0
DBN1-004
ENSP00000377195
ENST00000393565
Q16643 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0042641 [actomyosin]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0050773 [regulation of dendrite development]
Show all
 695 aa
76.3 kDa 		No 0
DBN1-006
ENSP00000423208
ENST00000512501
D6R9Q9 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005886 [plasma membrane]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
Show all
 391 aa
41.4 kDa 		No 0
DBN1-008
ENSP00000421465
ENST00000514833
D6RFI1 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0007015 [actin filament organization]
Show all
 124 aa
13.4 kDa 		No 0
DBN1-009
ENSP00000422854
ENST00000477391
D6R9W4 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0007015 [actin filament organization]
Show all
 317 aa
36.5 kDa 		No 0
DBN1-011
ENSP00000425546
ENST00000506117
D6RCR4 [Direct mapping]
Drebrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0007015 [actin filament organization]
Show all
 93 aa
10.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.