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ABCC5

GENERAL INFORMATION

Gene name

 ABCC5

Gene description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Protein class

 Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA052295
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ABCC5 (HGNC Symbol)

Synonyms

 EST277145, MOAT-C, MRP5, SMRP

Description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q27.1

Chromosome location (bp)

 183919934 - 184018015

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114770 (version 83.38)

Entrez gene

 10057

UniProt

 O15440 (UniProt - Evidence at protein level)

neXtProt

 NX_O15440

Antibodypedia

 ABCC5 antibodies

PROTEIN BROWSER
ABCC5-001
ABCC5-002
ABCC5-004
ABCC5-005
ABCC5-006
ABCC5-010
ABCC5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCC5-001
ENSP00000333926
ENST00000334444
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
 1437 aa
160.7 kDa 		No >9
ABCC5-002
ENSP00000390911
ENST00000446941
E9PET4 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 53 aa
6.2 kDa 		No 0
ABCC5-004
ENSP00000376358
ENST00000392579
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
 225 aa
25.3 kDa 		No 1
ABCC5-005
ENSP00000371934
ENST00000382494
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
 208 aa
23.7 kDa 		No 1
ABCC5-006
ENSP00000404809
ENST00000427120
A5PKY6 [Direct mapping]
ABCC5 protein; Multidrug resistance-associated protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 231 aa
26.2 kDa 		No 1
ABCC5-010
ENSP00000399726
ENST00000437341
C9JZL5 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 147 aa
16.7 kDa 		No 0
ABCC5-201
ENSP00000265586
ENST00000265586
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
 1394 aa
155.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.