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Positivity in extracellular matrix and stromal cells.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis] GO:0001775 [cell activation] GO:0001932 [regulation of protein phosphorylation] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0002931 [response to ischemia] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005577 [fibrinogen complex] GO:0005604 [basement membrane] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0006953 [acute-phase response] GO:0007044 [cell-substrate junction assembly] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007161 [calcium-independent cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008347 [glial cell migration] GO:0008360 [regulation of cell shape] GO:0009611 [response to wounding] GO:0010193 [response to ozone] GO:0010628 [positive regulation of gene expression] GO:0010952 [positive regulation of peptidase activity] GO:0016324 [apical plasma membrane] GO:0016504 [peptidase activator activity] GO:0018149 [peptide cross-linking] GO:0022617 [extracellular matrix disassembly] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030335 [positive regulation of cell migration] GO:0031012 [extracellular matrix] GO:0031093 [platelet alpha granule lumen] GO:0033622 [integrin activation] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0035987 [endodermal cell differentiation] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0042060 [wound healing] GO:0043066 [negative regulation of apoptotic process] GO:0045340 [mercury ion binding] GO:0045773 [positive regulation of axon extension] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050900 [leukocyte migration] GO:0050921 [positive regulation of chemotaxis] GO:0051384 [response to glucocorticoid] GO:0070062 [extracellular exosome] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071288 [cellular response to mercury ion] GO:0071333 [cellular response to glucose stimulus] GO:0071347 [cellular response to interleukin-1] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071773 [cellular response to BMP stimulus] GO:0072562 [blood microparticle] GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate] GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)